REVERSAL OF AGING with Epigenetic Reprogramming

First, we need a little background on Epigenetics

Each cell in your body has access to your full genome, or 3 billion base pairs. Each unique cell, however, does not need every gene for its function. A liver cell has a different function than a nerve cell.

Histones and DNA methylation
loops of DNA change as you get older

The Horvath Clock

In 2015, a study conducted by Steve Horvath introduced a novel way to measure biological age. It is based on the levels of methylation in your epigenome. There are 353 cytosine locations or CpG islands that are measured to see if there is a methyl group there. The more methylation you accumulate the older you are. This is known as the Horvath Clock.

transformation of our bodies

Yamanaka Factors

In 2012, Shinya Yamanaka won the Noble Prize for his usage of what is known as the Yamanaka Factors. The Yamanaka Factors are 4 genes that control transcription(transfer of DNA info to mRNA) in your body. What Yamanaka did was insert the four genes, through viral gene therapy (inserting the gene through a virus), into adult cells. Essentially, what the Yamanaka factors then do is wipe off all of the methylation in the cell which turns the adult cell into a stem cell.

very cool picture of a stem cell

Reversal of Aging

The culmination of these two tools led to techniques that could potentially reverse aging. Harvard graduate student, Yuangcheng Lu, who works at Sinclair Lab recently released a paper that could be groundbreaking in this field.

The nerve cell regenerated

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Aaron Lewis

Aaron Lewis

17 year-old AI and human longevity enthusiast