Metformin, AMPK, and Aging

Nir Barzilai and the TAME study that has major implications for longevity

What is AMPK and What Does it Do?

AMPK otherwise known as AMP activated kinase is a key node in the pathway in how cells regulate metabolism based on nutrient availability. AMPK is known as the “guardian of metabolism” for its importance.

Overview of all the things AMPK regulates

Most Important Functions

  • inhibits mTOR → tells the cell to stop growing
  • activates ULK1 → activates autophagy(breakdown of cellular/organelle junk)
  • activates ATGL→ fatty acid catabolism (breakdown)
  • inhibits ACC→ stops fatty acid synthesis
  • inhibits HMG-CoA reductase → stops cholestorol synthesis
  • activates TBC1D1 → more glucose uptake + glycolysis

How Does Metformin Effect AMPK?

You probably know metformin as the drug that is used for type 2 diabetes. Chances are you probably know someone who is on metformin as 78 million Americans were prescribed the drug in 2017. In type 2 diabetes, metformin is used to increase insulin sensitivity but research has shown it has effects that can increase longevity as well.



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